B.Sc., M.Sc., Ph.D.
physical: Building xx.x // The Station Crescent // Oteha Rohe
tel: +64 9 4140800 ext xxxxx // email: a.p.lind(at)massey.ac.nz
My PhD studies were completed in 2010 in Dan Andersson's group at Uppsala University in Sweden. The thesis focused on experimental work to investigate the mechanisms and dynamics of evolution in bacteria. Several research topics were studied including the influence of mutational biases on genome composition and the fitness effects of base pair substitutions and horizontal gene transfers as well as the molecular basis for these selective constraints and mutational pathways to compensate for the fitness costs.
I am interested in connecting mechanistic level insight of mutations to phenotype variation in order to improve our understanding of the principles of genetic evolution.
I am a post-doctoral research fellow supported by a Marsden Fund grant to unravel the principles of genetic evolution. Current work is focused on the evolution of wrinkly spreaders (WS) in a well-defined experimental system of bacterial populations of Pseudomonas fluorescens. The research aims to find all possible mutational pathways to the WS phenotype, the rate that mutation translates into phenotypic variation and an increased understanding of the genetic constraints governing the mutational pathways taken.
Lind P.A. and Andersson D.I. (2013) Fitness costs of synonymous mutations in the rpsT gene can be compensated by restoring mRNA base pairing. PLoS One 15;8(5):e63373.
Lind P.A., Berg O.G. and Andersson D.I. (2010) Mutational robustness of ribosomal protein genes. Science 330, 825-7.
Lind P.A., Tobin C., Berg O.G., Kurland C.G. and Andersson D.I. (2010) Compensatory gene amplification restores fitness after inter-species gene replacements. Molecular Microbiology75, 1078-89.
Lind P.A. and Andersson D.I. (2008) Whole-genome mutational biases in bacteria. Proceedings of the National Academy of Sciences, USA.105, 17878-83.