physical: Building 16.x // The Station Crescent // Oteha Rohe
tel: +64 9 4140800 ext 41107 // email: tiena27(at)gmail.com
I complete my BSc at Nanchang University of China. I have done my postgraduate diploma at Massey University in New Zealand. Studies of Saccharomyces cerevisiae response to amino acids starvation may provide sufficient understanding of how the mechanism will operate in human disease study. Recently, some studies have demonstrated that cancer cell starving for certain amino acids cause acceleration in cell death. The specific influence of SM in S. cerevisiae cell is a rapid depletion of isoleucine and valine, which triggers the GAAC response.
My research focus on genetic analysis succinate utilization genes of Pseudomonas fluorescens SBW25
The primary aim of this study is to elucidate the molecular mechanisms employed by P. fluorescens SBW25 to utilize C4-dicarboxylates, succinate in particular. Succinate, an intermediate of the tricarboxylic acid (TCA) cycle, is one of the most preferred nutritional substrates for bacteria, particularly those capable of colonizing eukaryotic hosts such as plants, animals (including humans). The genetic mechanisms of succinate utilization have been well studied in E. coli and other model microorganisms such as rhizobia; however, the succinate utilization genes remain unknown in P. fluorescens SBW25. Therefore, this work is to identify and characterize succinate-specific transporter(s) and related genes.